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KEY POINTS:
Managing Weight-Related Conditions
1. Obesity causes or exacerbates a wide range of diseases through
metabolic, mechanical, and psychological pathways.
2. Weight reduction improves these comorbidities through both
direct and indirect effects.
3. Use guideline-based, weight-sensitive medications that support
metabolic improvement and avoid weight gain.
4. Prioritize agents that promote weight loss in insulin resistance,
prediabetes, and type 2 diabetes (e.g., glucagon-like peptide 1
receptor agonists [GLP-1 RAs], dual incretin agonists, and sodium-
glucose cotransporter 2 [SGLT2] inhibitors).
5. Deprescribe or titrate antihypertensive, lipid-lowering, and
glucose-lowering medications as metabolic control improves
with weight loss.
6. Identify and treat MASLD early; modest weight loss (≥5% to 10%)
often reverses steatosis.
7. Address musculoskeletal and reflux-related conditions that limit
physical activity; adapt exercise prescriptions accordingly.
8. Evaluate for and manage obesity-related neuroendocrine
disorders such as PCOS and idiopathic intracranial hypertension in
collaboration with specialists.
9. Screen for and treat behavioral and psychiatric comorbidities
(e.g., binge-eating disorder, depression, attention-deficit
hyperactivity disorder) that interfere with weight loss success.
Management
