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Table 23. Physiological and Secondary Causes of
Hypertriglyceridemia
Categories
Conditions and Medications Contributing to
Hypertriglyceridemia
Drugs*
(Medications)
Anesthesia:
• Propofol
Cardiology:
• Beta-adrenergic–blocking agents
• Thiazide and loop diuretic agents
• Bile acid sequestrants (cholestyramine, colestipol, colesevelam)
Endocrine:
• Glucocorticosteroids
• Anabolic steroids
• Oral estrogens
» Raloxifene
» Clomiphene citrate
» Estradiol
» Ethinyl estradiol
» Conjugated estrogens
» Tamoxifen
Dermatology:
• Isotretinoin
Infectious Disease:
• HIV protease inhibitors
Oncology:
• Tamoxifen
• L-asparaginase
• Bexarotene
• Cyclophosphamide
Psychiatry:
• Atypical antipsychotic agents (eg, olanzapine, mirtazapine,
clozapine)
Immunosuppressive agents:
• Tacrolimus
• Sirolimus
• Cyclosporine
• Interferons
Disorders of
metabolism
• Overweight and obesity
• Metabolic syndrome/insulin resistance
• Weight gain after weight loss
Physiological • Pregnancy (especially during the third trimester, when pregnancy-
associated TG elevation is peaking )
* Caveats: TG-raising medications require careful monitoring ; minimizing other conditions
that raise TG; and, when clinically appropriate, using alternatives.
TG indicates triglycerides.
Adapted from Virani et al.
(cont'd)
