55
1
Continue moderate-
intensity statin
†
1
Monitor adherence
and response to therapy
1
Engage in benefit-risk
discussion
2b
Start moderate-intensity
statin therapy
†
PREVENT-ASCVD 10-y
risk ≥10% or multiple
ASCVD risk factors?
LDL-C <70 mg/dL and
non–HDL-C <100 mg/dL?
NO
NO
YES
YES
Adults with diabetes but
without ASCVD
40–75 y of age >75 y of age
Optional apoB goal <90 mg/dL
1
Start moderate-intensity statin
†
Goal: ≥30%–49% LDL-C
reduction, LDL-C <100 mg/dL,
and non–HDL-C <130 md/dL
AND
Optional apoB goal
<70 mg/dL
2b
Add ezetimibe or
PCSK9 mAb
Goal: ≥50% LDL-C
reduction, LDL-C <70
and non–HDL-C <100
AND
Optional apoB goal <70 mg/dL
2a
Increase high-intensity statin
†
Goal: ≥50% LDL-C reduction, LDL-C
<70 mg/dL, and non–HDL-C <100 md/dL
AND
