50
Management
Figure 8. Evaluation and Management of HoFH
Adults with clinical or genetic
information of HoFH
1
Cascade screen all
first-degree relatives and
complete genetic testing
1
Consult lipid specialist
for advanced LDL–C-
lowering therapies
and/or LDL apheresis
2b
Add lomitapide with
hepatic function
monitoring
NO
NO
2b
Add evinacumab
LDL-C <100 mg/dL?
2a
Add ezetimibe,
PCSK9 mAb, and/or
bempedoic acid
1
Initiate maximally
tolerated statin
AND
LDL-C <100 mg/dL?
