102
Complications of Management
5.2. Statin-Cardiovascular Drug Interactions
COR LOE
Recommendation
1 B-NR
1. In adults for whom the decision is made to initiate statin
therapy, a review of concomitant medications and assessment
for potential DDI with other cardiovascular medications
is recommended to minimize the risk of statin-associated
adverse events.
Table 27. Clinical Recommendations on Management of DDI
With Statins and Cardiovascular Medications
Interacting Drug Statin Clinical Recommendation for Management
Amiodarone Lovastatin Limit dose of lovastatin to 40 mg daily
Simvastatin Limit dose of simvastatin to 20 mg daily
Amlodipine Lovastatin Limit dose of lovastatin to 20 mg daily
Simvastatin Limit dose of simvastatin to 20 mg daily
Bempedoic acid Pravastatin Limit dose of pravastatin to 40 mg daily
Simvastatin Limit dose of simvastatin to 20 mg daily
Colchicine Atorvastatin Closer monitoring for muscle-related toxicity is
recommended when used in combination
Fluvastatin
Lovastatin
Pitavastatin
Pravastatin
Rosuvastatin
Simvastatin
Conivaptan Lovastatin Avoid combination
Simvastatin Avoid combination
Diltiazem Lovastatin Limit dose of lovastatin to 20 mg daily
Simvastatin Limit dose of simvastatin to 10 mg daily
Dronedarone Lovastatin Limit dose of lovastatin to 10 mg daily
Simvastatin Limit dose of simvastatin to 10 mg daily
