64
Management
Figure 13. Managing Adults With Subclinical Atherosclerosis
CAC = 1 to 99 AU and
<75th percentile for
age, sex, race
Management of patients with
subclinical atherosclerosis
Severe:
CAC ≥300 to 999 AU
Optional apoB goal
<70 mg/dL
Optional apoB goal
<55 mg/dL
CAC ≥100 to 299 AU
or ≥75th percentile
for age, sex, race
2a
Start moderate-
intensity statin
Goal: ≥30%–49%
LDL-C reduction;
LDL-C <100 mg/dL
and non–HDL-C
<130 mg/dL
1
Start LDL–C-
lowering therapy
Goal: ≥50% LDL-C
reduction;
LDL-C <70 mg/dL
and non–HDL-C
<100 mg/dL
1
Start LDL–C-
lowering therapy
Goal: ≥50% LDL-C
reduction;
LDL-C <70 mg/dL
and non–HDL-C
<100 mg/dL
2a
Optional goal:
LDL-C of <55 mg/dL
and non–HDL-C
<85 md/dL
apoB indicates apolipoprotein B; AU, Agatston Units; CAC,
coronary artery calcium; CT, computed tomography; HDL-C,
high-density lipoprotein-cholesterol; and LDL-C, low-density
lipoprotein-cholesterol.
