26
Management
Table 8. Common Medications That May Interact With
Statins
Avoid use with any
statin
Can be used with a statin using a risk mitigation
strategy*
Gemfibrozil • Amiodarone
• Amlodipine
• Atazanavir plus ritonavir
• Boceprevir
• Clarithromycin
• Cobicistat-containing
products
• Colchicine
• Cyclosporine
• Danazol
• Darunavir plus ritonavir
• Diltiazem
• Dronedarone
• Erythromycin
• Fenofibrate
• Fenofibric acid
• Fluconazole
• Fosamprenavir
(with or without ritonavir)
• Itraconazole
• Ketoconazole
• Lomitapide
• Lopinavir plus ritonavir
• Nefazodone
• Nelfinavir
• Niacin (≥1 g/d)
• Nirmatrelvir plus ritonavir
• Posaconazole
• Ranolazine
• Rifampin
• Saquinavir plus ritonavir
• Telaprevir
• Telithromycin
• Tipranavir plus ritonavir
• Verapamil
• Voriconazole
• Warfarin
* Risk mitigation strategies include a) avoiding use of the coadministered interacting medication,
b) using an alternative statin that does not have the drug-drug interaction, and c) limiting the
statin dose depending upon the statin and the nature of the drug-drug interaction.
Modified with permission from Wiggins et al. Copyright © 2016 American Heart
Association, Inc.
