24
Management
Table 7. Pharmacokinetic Properties of Statin Medications
Absorption Distribution
Bio-availability (%) Tmax (h)
Protein
Binding (%)
Lipophilicity
(log P )
Atorvastatin 14 1–2 ≥98 Yes, 4.1
Fluvastatin 24 <1 98 Yes, 3.2
Lovastatin <5 2–4 ≥95 Yes, 4.3
Pitavastatin 43–51 1 99 Yes, 1.5
Pravastatin 17 1–1.5 50 No, –0.2
Rosuvastatin 20 3–5 88 No, –0.3
Simvastatin <5 4 95 Yes, 4.7
Atorvastatin, lovastatin, and simvastatin are P-glycoprotein substrates and may be subject to
certain drug-drug interactions.
Modified with permission from Wiggins et al. Copyright © 2016 American Heart Association, Inc.
CYP indicates cytochrome P450; h, hour; Tmax, time until maximum serum concentration
achieved; and t1/2, drug half-life.
