46
General Supportive Early Management
Figure 4. DAPT for Minor Noncardioembolic AIS and TIA
Acute noncardioembolic
ischemic stroke or TIA
NO
NO
DAPT
2b
Ticagrelor + Asa
×
21 days
1
Eligible for
revascularization?
1
CYP2C19
Loss of function
allele carrier
NO
YES
NO
YES
1
LKN <24 hr
1
NIHSS ≤3
ABCD2 ≥4
1
NIHSS 4–5
YES
CHANCE 2
Allele testing
DAPT
CHANCE
POINT
THALES
2b
Ticagrelor + Asa
×
30 days
1
Clopidogrel + Asa
×
21–90 days
OR
NO YES
LEGEND
(Class of Recommendation)
COR 2b
COR 3-No Benefit
COR 3-Harm
COR 2a
COR 1
