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Adult Sinusitis - 2025 Update

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12 Management KAS 1 KAS 1 KAS 1 KAS 6 Prescribe amoxicillin, with or without clavulanate for 5–7 days Manage complication Recommend symptomatic relief for ABRS Change the prescribed antibiotic Offer watchful waiting a Viral upper respiratory infection (URI) YES YES YES YES YES Meets criteria for ARS? Meets criteria for ABRS? Complication suspected? Treatment failure? b Confirm DX? Complication presented? Complication presented? Improvement? NO NO NO NO NO NO NO NO Clinician judgment as to whether patient should be managed more like ARS or CRS If penicillin allergy, prescribe doxycycline or a third generation cephalosporin w/wo clindamycin DURATION: >4 WEEKS and <12 WEEKS DURATION: <4 WEEKS KAS 5 KAS 3 KAS 6 KAS 4 KAS 1B KAS 2 KAS 2 Adult with possible sinusitis "Subacute" sinusitis excluded from guideline Obtain radiological imaging Manage complications and ABRS Management complete Management complete Continue to assess for improvement Treat correct diagnosis Do not obtain radiological imaging May recommend symptom relief for VRS Figure 5. Adult With Possible Rhinosinusitis YES YES YES ABRS

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