5
Table 3. Outcome Measures and Endoscopic Grading Systems
Metric
category
Instrument
name Description Scoring details
Minimal
clinically
important
difference
(MCID)
Quality of
life scores
22-Item
Sinonasal
Outcome Test
(SNOT-22)
• A patient-
reported
outcome
measure
assessing
symptoms and
their impact on
daily life related
to sinonasal
conditions.
• Variants that
assess related
productivity
and impact of
allerg y are also
available.
Each of the 22 items is
rated on a scale from 0
to 5, with 0 indicating
no problem and 5
indicating the most
severe problem. Total
scores range from 0
to 110.
Additional scoring
is available for
productivity and allerg y.
8.9, 12
a
Rhinosinusitis
Disability
Index (RSDI)
A questionnaire
measuring
the impact of
rhinosinusitis
on physical,
functional, and
emotional aspects
of daily life.
Responses to 30 items
are scored from 0 to
4, with higher scores
indicating greater
disability. Total scores
range from 0 to 120.
10.35
CRS PRO Questionnaire
defined with
patient input per
Food and Drug
Administration
guidance on
patient-reported
outcome measures
acceptable for use
as end points in
clinical trials.
12-Item Likert scale
survey with scores
ranging from 0 to 4,
from symptoms not
bothersome at all to
4 as the most severe.
Total scores range from
0 to 48.
6
Diagnosis and Treatment
