12
Treatment
Table 3. Potential Treatment Agents for Treatment of the
Primary C. difficile Infection (CDI) Episode
Agent Adult Dose Cost
a
Initial
Treatment
Response
Recurrence
Risk
Proven Efficacy
Bezlotoxumab 10 mg/kg IV once $$$$ 0
(adjunct only)
++
Fidaxomicin 200 mg PO bid ×
10 days
$$$$ +++ +
Vancomycin 125 mg PO qid ×
10 days
$$$$
$ (Liq)
+++ ++
Metronidazole 500 mg PO tid ×
10 days
$ ++ ++
Probable Efficacy
Nitazoxanide 500 mg PO bid ×
10 days
$$ +++ ++
Fusidic acid 250 mg PO tid ×
10 days
N/A in
USA
++ ++
Inadequate Data To Support Efficacy
Rifaximin 400 mg PO tid ×
10 days
$$$ ++ +?
Tigecycline 50 mg IV every bid
× 10 days
$$$$ ++? ?
Bacitracin 25,000 units PO
qid × 10 days
$$ + +?
a
All prices are estimated in US dollars as quoted from Red Book Online Search, Micromedex
Solutions, last accessed on March 10, 2015 or approximated hospital pharmacy pricing (tigecycline,
bacitracin).
$: $0–100; $$: $101–500; $$$: $501–1000; $$$$: >$1000
