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is resource is for informational purposes only, intended as a quick-reference tool based on the
cited source guideline(s), and should not be used as a substitute for the independent professional
judgment of healthcare providers. Practice guidelines are unable to account for every individual
variation among patients or take the place of clinician judgment, and the ultimate decision
concerning the propriety of any course of conduct must be made by healthcare providers aer
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Abbreviations
CA, community-associated; CDI, Clostridioides difficile infection; CO-HCFA,
community-onset healthcare facility-associated; CXR, chest radiograph; EIA, enzyme
immunoassays; GDH, glutamate dehydrogenase; HIV, human immunodeficiency virus;
HO-CDI, healthcare facility-onset C. difficile infection; HPLC, high-performance
liquid chromatography; IGRA, interferon-γ release assay; IV, intravenous; LTBI,
latent tuberculosis infection; Mtb, Mycobacterium tuberculosis; NAAT, nucleic acid
amplification test; PO, by mouth; PPI, proton pump inhibitors; PR, per rectum; RCT,
randomized clinical trial; RR, relative risk; SOC, standard-of-care;TB, tuberculosis; TST,
tuberculin skin test
e guidelines provide evidence-based recommendations that have been developed
using GR ADE (Grading of Recommendations, Assessment, Development, and
Evaluation) methodolog y. GR ADE involves structured literature review, systematic
reviews and meta-analyses of combined data, and expert discussion to assess the
certainty in the evidence and determine the strength of each recommendation.
Source
Johnson S, Lavergne V, Skinner AM, et al. Clinical Practice Guideline by the Infectious
Diseases Society of America (IDSA) and Society for Healthcare Epidemiolog y of America
(SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile
Infection in Adults. Clin Infect Dis, 2021; 73(5), e1029-e1044. doi: 10.1093/cid/ciab549
McDonald LC, Gerding DN, Johnson S, et al. Clinical Practice Guidelines for
Clostridioides difficile Infection in Adults and Children: 2017 Update by the Infectious
Diseases Society of America (IDSA) and Society for Healthcare Epidemiolog y of America
(SHEA). Clin Infect Dis 2018; 66(7): e1-e48.
e guidelines were endorsed by the American Society for Health Systems Pharmacists
(ASHP), the Society of Infectious Diseases Pharmacists (SIDP), and the Pediatric
Infectious Diseases Society (PIDS).
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