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Disclaimer
is resource is for informational purposes only, intended as a quick-reference tool based on the cited
source guideline(s), and should not be used as a substitute for the independent professional judgment
of healthcare providers. Practice guidelines are unable to account for every individual variation
among patients or take the place of clinician judgment, and the ultimate decision concerning the
propriety of any course of conduct must be made by healthcare providers aer consideration of
each individual patient situation. Guideline Central does not endorse any specific guideline(s) or
guideline recommendations and has not independently verified the accuracy hereof. Any use of this
resource or any other Guideline Central resources is strictly voluntary.
Abbreviations
BMI, body mass index; CLABSI, central line-associated bloodstream infection; CVC, central
venous catheter; HCP, healthcare personnel; ICU, intensive care unit; PICC, peripherally-
inserted central venous catheters; rt-PA, recombinant tissue plasminogen activating factor
Source
Buetti N, Marschall J, Drees M, et al. Strategies to prevent central line-associated bloodstream
infections in acute-care hospitals: 2022 Update. Infection Control & Hospital Epidemiolog y.
2022;43(5):553-569. doi:10.1017/ice.2022.87
Recommendation Grading
Category Definition
H = High Highly confident that the true effect lies close to that of the estimated
size and direction of the effect. Evidence is rated as "High" quality when
there are a wide range of studies with no major limitations, there is
little variation between studies, and the summary estimate has a narrow
confidence interval.
M = Moderate
e true effect is likely to be close to the estimated size and direction of the
effect, but there is a possibility that it is substantially different. Evidence is
rated as "Moderate" quality when there are only a few studies and some have
limitations but not major flaws, there is some variation between studies, or
the confidence interval of the summary estimate is wide.
L = Low e true effect may be substantially different from the estimated size and
direction of the effect. Evidence is rated as "Low" quality when supporting
studies have major flaws, there is important variation between studies, the
confidence interval of the summary estimate is very wide, or there are no
rigorous studies.
