Appendices
42
Appendix A: Antipsychotic Agents
Antipsychotic
a
Generic Name
(Brand Name) Indications and Dosage
Quetiapine (Seroquel
®
)
Major Depressive Disorder (in combination with
antidepressants):
• Oral: Extended Release (ER) – 50 mg daily; may increase
by 50 mg once daily to an effective dose. (max: 300 mg
daily)
Agitation associated with dementia (off-label):
• Oral: Immediate Release (IR) – 25 to 75 mg daily in 1 to
2 divided doses; increase gradually based on response and
tolerability (max: 400–800 mg per day). If no response in
4 weeks, begin taper to discontinuation.
Agitation associated with delirium (off-label):
• Oral: Immediate Release (IR) – 50 mg twice daily; may
increase as necessary (max: 400 mg per day)
Psychosis in Parkinson Disease (off-label):
• Oral: Immediate Release (IR) – 25 mg daily in 1 to 2
divided doses; increase gradually based on response and
tolerability (max: 200 mg per day).
Risperidone
(Risperdal
®
)
Major Depressive Disorder (in combination with
antidepressants):
• Oral: 0.25 to 0.5 mg daily; increase based on response and
tolerability (max: 3 mg per day)
Agitation associated with delirium (off-label):
• Oral: 0.25 mg twice daily; increase based on response and
tolerability (max: 4 mg per day with a lower max if >65
years of age)
Psychosis in Parkinson Disease (off-label):
• Oral: 0.5 mg daily in 1 or 2 divided doses; increasing based
on response and tolerability (max: 2 mg per day).
Doses >1 mg daily are associated with higher risk of
extrapyramidal systems. If no response in 4 weeks, begin
taper to discontinuation.
Ziprasidone (Geodon
®
)
Major Depressive Disorder (in combination with
antidepressants) (off-label):
• Oral: 20 mg twice daily; may increase dose by 20 mg
twice daily at weekly increments based on response and
tolerability (max: 80 mg twice daily)
Psychosis in Parkinson Disease (off-label):
• Oral: 20 to 40 mg daily in 1 to 2 divided dose; increase
daily dose by 20 to 40 mg increments every 2 to 7 days
(max: 160 mg per day). If no response in 4 weeks, begin
taper to discontinuation.
a
Other antipsychotic agents such as Lurasidone (Latuda) and Brexpiprazole (Rexulti) may be
recommended by a psychiatrist for certain clinical conditions.
