Appendices
38
Appendix A: Antipsychotic Agents
Antipsychotic
a
Generic Name
(Brand Name) Indications and Dosage
For all antipsychotics listed below: Black Box Warning - Increased mortality in elderly
patients with dementia-related psychosis
Aripiprazole (Abilify
®
)
Adjunctive therapy for depression (used with an
antidepressant):
• Oral: 2 to 5 mg/day (max: 15 mg/day)
Acute Agitation:
• IM: 5.25 to 15 mg once; a repeat dose up to 5 mg ; may be
given at >2 hour intervals. (max: 30 mg/day)
Agitation associated with dementia (off-label):
• Oral: 2 to 5 mg daily (max: 15 mg daily)
• IM: 2.5 to 10 mg once; a repeat dose of up to 5 mg may be
given at >2 hour intervals (max: 15 mg/day)
• If no response in 4 weeks, begin taper to discontinuation.
Clozapine (Clozaril
®
)
Psychosis in Parkinson Disease (off label):
• Oral: 6.25 mg daily in 1 or 2 divided doses, increase based
on response and tolerability every 3 to 7 days (max: 50 mg
per day)
Treatment-resistant agitation associated with dementia
(off-label):
• Oral: 12.5 mg at bedtime titrate by 12.5 mg every 3 to 5
days as needed
