39
Adverse Drug Reactions (ADR) Cost
Potential ADRs:
• Altered cardiac conduction (QTc prolongation), blood dyscrasias,
central nervous system (CNS) depression, dyslipidemia,
extrapyramidal symptoms, hyperglycemia, neuroleptic malignant
syndrome, orthostatic hypotension (falls), weight gain
Oral: $$
Syringe: $$$$
Black Box Warning: Severe neutropenia
Compared to the other antipsychotics, this agent has the highest risk
of neutropenia:
• Prior to initiation, obtain baseline CBC including the absolute
neutrophil count (ANC) which must be ≥1,500/mcL. Monitor
regularly.
Potential ADRs:
• Anticholinergic effects, orthostatic hypotension, bradycardia, syncope,
falls, myocarditis, CNS depression, dyslipidemia, eosinophilia,
extrapyramidal symptoms, hepatotoxicity, hyperglycemia, neuroleptic
malignant syndrome, QTc prolongation, seizures, weight gain.
$
