11
Cost
Benefit-Harm
Assessment Policy Level
Moderate to
High
Benefits appear to
outweigh harm
Option: Corticosteroid-eluting implants
can be considered as an option in a
previously operated ethmoid cavity with
recurrent nasal polyps
High Likely benefit over
harm in patients
with CRSwNP not
responsive to medical
and surgical standard
of care
Recommendation: May be considered for
patients with severe CRSwNP who have
not improved despite other medical and
surgical treatment options
Low Benefits appear to
outweigh harm
Option: Macrolides are an option for
patients with CRSsNP. Optimal drug,
dosage, and treatment duration are not
known
Low Benefits appear to
outweigh harm
Option: Macrolides are likely beneficial
in CRSwNP. Optimal drug, dosage, and
treatment duration are not known
Variable Preponderance of harm
over benefits
Recommendation against: Should
generally not be prescribed for CRSwNP
except in acute exacerbations
Moderate to
High
Relative harm over
benefit
Recommendation against: Topical
antibiotics are not recommended for
CRSs/wNP
Low to
Moderate
Minimal risk of harm
but no apparent
potential for benefit
Strong recommendation against: Topical
antifungals are not recommended for
CRSs/wNP
