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38 Hypertension in Patients With Comorbidities Figure 8. Management of Hypertension in Patients With Acute Ischemic Stroke Acute (<72 h from symptom onset) ischemic stroke and elevated BP Patient qualifies for IV thrombolysis therapy Lower SBP to <185 mm Hg and DBP <110 mm Hg before initiation of IV thrombolysis (Class I) Colors correspond to Class of Recommendation on page 56–57. Lower BP 15% during first 24 h (Class IIb) YES NO BP ≤220/110 mm Hg For preexisting hypertension, reinitiate antithypertensive drugs after neurological stability (Class IIa) BP >220/110 mm Hg Initiating or reinitiating treatment of hypertension within the first 48–72 hours after an acute ischemic stroke is ineffective to preven death or dependency (Class III: No Benefit) And Maintain BP <180/105 mm Hg for first 24 h after IV thrombosis (Class I)

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