Table 3. Non-Modifiable Risk Factors at Baseline
Increased Risk
No Increased
Risk
Point
Estimate
a
Confidence
Misery perfusion (SPECT) 31.5 High
Impaired flow (vs complete) 5.9 Low
Qualifying infarct = borderzone 3.1 Low
Low distal flow status on
quantitative magnetic resonance
angiography (QMRA)
3.4 Low
>70% stenosis (vs 50%–69%) 2.0 High
Anterior vs
posterior
circulation
1.0 High
National Institutes of Health
Stroke Scale >1
1.8 High
Stroke as qualifying event (QE) 0.6 High
Old infarcts 3.3 Moderate
Time from QE <17 days 0.6 Moderate
Qualifying infarct =
borderzone plus impaired
collaterals
6.9 Low
Sex (female) 0.6 High
Age
(lower ref. group)
1.1 Low
Non-White vs
White
1.2 Low
a
e evidence is insufficient to support or refute the following non-modifiable risk factors
in predicting an increased risk of recurrent stroke: history of stroke, history of transient
ischemic attack (TIA), time from QE (when dichotomized at <7 days), concomitant
small vessel disease (SVD), concomitant ICAS, not being on a statin, baseline modified
Rankin Scale score ≥1, percent stenosis of >80% vs 70%–79%, length of stenosis, white
blood cell count of >7200, neutrophil count, progression of stenosis on MRA, increased
oxygen extraction fraction (OEF) asymmetry (PET scan), and hypoperfusion patterns
on imaging.
Classification of Management Recommendations
Classification Definition
Level A
Denotes a practice recommendation that must be done. In
almost all circumstances, adherence to the recommendation
will improve health-related outcomes. Almost all patients in
this circumstance would desire that the recommendation be
followed.
Level B
Indicates a recommendation that should be done. In most
circumstances, adherence to the recommendation will likely
improve health-related outcomes. Most patients in this
circumstance would want the recommendation to be followed.
Level C
Represents a recommendation that may be done. In some
circumstances, adherence to the recommendation might
improve health-related outcomes.
Level U
Indicates that the available evidence is insufficient to support
or refute the efficacy of an intervention.
Level R
Assigned when the balance of benefits and harms is unknown
and the intervention is known to be exorbitantly expensive
or have important risks. is level designates that the
intervention should not be used outside of a research setting.
Treatment
