54
Special Populations
Table 20. CARPREG II Risk Prediction Model
CARPREG II Predictors Points
Previous cardiac event or arrhythmia 3
Baseline NYHA functional class III to IV or cyanosis 3
Mechanical valve 3
Ventricular dysfunction 2
High-risk le-sided valve disease and LVOT obstruction 2
Pulmonary hypertension 2
CAD 2
High-risk aortopathy 2
No previous cardiac intervention 1
Late pregnancy assessment 1
CARPREG II Score Predicted Risk, %
0 to 1 5
2 10
3 15
4 22
>4 41
e CARPREG (Cardiac Disease in Pregnancy Study) II risk score is based on 10 predictors,
shown in the box. Each predictor is assigned a weighted point score. e sum of points
represents the risk score. Risk scores are categorized into 5 groups. e predicted and observed
frequency of primary cardiac events* in the derivation and validation groups are available here:
the CARPREG II Study (https://pubmed.ncbi.nlm.nih.gov/29793631/).
* Primary cardiac events were defined as any of these: maternal cardiac death, cardiac arrest,
sustained arrhythmia requiring treatment, le-sided HF defined as pulmonary edema, right-
sided HF, stroke or TIA, cardiac thromboembolism, MI, and vascular dissection.
Modified with permission from Silversides CK, et al. J Am Coll Cardiol. 2018;71:2419-2430.
Copyright 2018 American College of Cardiolog y Foundation.
