Treatment
Figure 1. Class Effects for the Most Well-Studied Oral
Treatments of Painful Diabetic Polyneuropathy
e effects of different oral medication classes on painful diabetic neuropathy including gabapentinoids,
serotonin-norepinephrine reuptake inhibitors (SNRIs), sodium channel blockers, SNRI/opioid dual
mechanism agents, and tricyclic antidepressants (TCAs).
