Table 1. Recommended Treatment Options for Painful
Diabetic Neuropathy
Medications
Medication Class Generic/Brand
Topical Medications
Capsaicin (Prescription) Capsaicin/Qutenza
Capsaicin (Over the Counter) Capsaicin/many
Oral Medications
Serotonin-norepinephrine reuptake
inhibitor (SNRIs)
Duloxetine/Cymbalta
Venlafaxine/Effexor
Desvenlafaxine/Pristiq, Khedezia
Gabapentinoids Gabapentin/Neurontin
Pregabalin/Lyrica
Sodium channel antagonist Oxcarbazepine/Oxtellar
Lamotrigine/Lamictal
Lacosamide/Vimpat
Tricyclic antidepressants (TCAs) Amitriptyline/Elavil, others
Nontraditional and Nonpharmacologic
Cognitive behavioral therapy (CBT)
Exercise
Tai Chi
Mindfulness
