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PARP Inhibitors in the Management of Ovarian Cancer

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Treatment Standard of Care Figure 1. PARPi Use Opportunities in PARPi-Naïve Women with Stage * Recommendations are color coded: Green indicates recommendations; yellow indicates considerations for use. is figure should not be interpreted as justification for PARPi use in >1 of these settings. Disease Life Cycle PARPi Recommendations CT ± bevacizumab Bevacizumab maintenance Platinum combination ± bevacizumab Bevacizumab maintenance Diagnosis End first-line therapy Platinum sensitive recurrence PARPi maintenance PARPi treatment OR OR May be used Recommended Chemotherapy ± bevacizumab ➞ PARPi + bev

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