Table 1. Dose Modification for PARPi
Starting
Dose
Initial
Dose
Reduction
2nd Dose
Reduction
3rd Dose
Reduction
Final
Reduction
Olaparib 300 mg
every 12
hours
200 mg*
every 12
hours
150 mg*
every 12
hours
Discontinue –
Rucaparib 600 mg
every 12
hours
500 mg
every 12
hours
400 mg
every 12
hours
300 mg
every 12
hours
Discontinue
Niraparib 300 mg
once daily
200 mg
once daily
100 mg
once daily
Discontinue –
Niraparib if
weight <77 kg
and/or platelets
counts below
150,000/µL
(UK based on
weight <58 kg )
200 mg
once daily
100 mg once
daily
Discontinue – –
* Dose reductions are based on general practice standard and deviate slightly from AstraZeneca's
Prescribing Information
