Identification of Candidates for
Outpatient Management
Table 2. MASCC Scoring System to Identify Patients With
Cancer and Febrile Neutropenia at Low Risk of Medical
Complications
a
Characteristic Weight
Burden of febrile neutropenia with no or mild symptoms
b
5
No hypotension (systolic blood pressure >90 mmHg ) 5
No chronic obstructive pulmonary disease
c
4
Solid tumor or hematologic malignancy with no previous fungal infection
d
4
No dehydration requiring parenteral fluids 3
Burden of febrile neutropenia with moderate symptoms
b
3
Outpatient status 3
Age <60 years 2
a
Maximum score is 26; scores ≥21 indicate a low risk for medical complications.
b
Burden of febrile neutropenia refers to the general clinical status of the patient as influenced by the
febrile neutropenic episode. It should be evaluated on the following scale: no or mild symptoms (score
of 5), moderate symptoms (score of 3), and severe symptoms or moribund (score of 0). Scores of 3 and 5
are not cumulative.
c
Chronic obstructive pulmonary disease means active chronic bronchitis, emphysema, decrease in forced
expiratory volumes, or need for oxygen therapy and/or steroids and/or bronchodilators requiring
treatment at the presentation of the febrile neutropenic episode.
d
Previous fungal infection means demonstrated fungal infection or empirically treated suspected fungal
infection.
