12
Treatment
Table 5. First-Line Treatment
Population Rec #
RAS unknown 2.1
RAS WT and right-sided primary tumor 2.2
RAS WT and le-sided primary tumor 2.3
RAS WT ± BRAF MUT, patients with good PS and without major
comorbidities, and /or when tumor shrinkage is the goal
2.4
RAS WT and preexisting neuropathy, elderly, comorbidities, or not
candidates for aggressive chemotherapy
2.5
RAS WT and preexisting neuropathy, elderly, comorbidities, or not
candidates for chemotherapy
2.6
RAS WT and very poor performance status (PS 3–4) or comorbidities 2.7
