Summary of Recommendations
Interventions
Strength of
recommendation
Strength of
the evidence Benefits Harms
a
Goshajinkigan
(GJG) – Kampo
medicine
Moderate against Intermediate Low Low
Metformin Moderate against Intermediate Low Low
Minocycline Moderate against Intermediate Low Low
Nimodipine Moderate against Intermediate No evidence of
efficacy
Moderate
Omega 3 Moderate against Intermediate Low Low
Org 2766 Moderate against Intermediate Low Low
Retinoic Acid Moderate against Intermediate Low Moderate
rhuLIF Moderate against Intermediate No evidence of
efficacy
Low
Venlafaxine Moderate against Intermediate Moderate Moderate
Vitamin B Moderate against Intermediate Low Low
Vitamin E Moderate against Intermediate Low Low
Treatment
Acupuncture No recommendation Low Low Low
Duloxetine Moderate for Intermediate Moderate Low
Exercise No recommendation Low Low Low
Gabapentin/
pregabalin
No recommendation Low Low Low
Topical
Amitriptyline,
Ketamine, +/-
Baclofen (BAK)
No recommendation Low Low Low
Oral cannabinoids No recommendation Low Low Low
Tricyclic
antidepressants
No recommendation Low Low Low
Scrambler
erapy
No recommendation Low Low Low
a
"Harms" are based only on the results of the specific clinical trials in the previous tables and not on
any other evaluations of the safety of these treatments.
