30
Treatment
Table 13. Selected Prescription Medications That May Cause
or Exacerbate HF
Drug or
Therapeutic Class
Associated With HF
Magnitude of
HF Induction or
Precipitation
Causes Direct
Myocardial
Toxicity
Exacerbates
Underlying
Myocardial
Dysfunction
COX, nonselective
inhibitors
(NSAIDs)
X Major
COX, selective
inhibitors (COX-2
inhibitors)
X Major
iazolidinediones X Major
Saxagliptin X Major
Alogliptin X Major
Flecainide X Major
Disopyramide X Major
Sotalol X Major
Dronedarone X Major
Alpha-1 blockers
Doxazosin X Moderate
Diltiazem X Major
Verapamil X Major
Nifedipine X Moderate
