32
Treatment
Table 7. Oral and Parental Antiplatelet Agents for Patients
Undergoing PCI
Drug Loading Dose Maintenance Dose
Oral antiplatelet agents
Aspirin • Loading dose of 162–325 mg
orally
• Aspirin may be chewed to
achieve faster action
Maintenance dose of 75–100 mg
orally daily
Clopidogrel • Loading dose of 600 mg orally
• A lower loading dose of 300
mg should be considered in
patients after fibrinolytic
therapy
Maintenance dose of 75 mg orally
daily
Prasugrel
Loading dose of 60 mg orally
• Maintenance dose of 10 mg
orally daily
• In patients with body weight
<60 kg, a maintenance
dose of 5 mg orally daily is
recommended
• In patients ≥75 years of age, a
dose of 5 mg orally daily can be
used if deemed necessary
Ticagrelor • Loading dose of 180 mg orally
• Ticagrelor may be chewed to
achieve faster action
Maintenance dose of 90 mg orally
twice a day
Intravenous antiplatelet agents
Abciximab
(GPI)*
Bolus of 0.25 mg/kg Maintenance of 0.125 µg/kg/min
infusion (maximum
10 g/min) for 12 hours
Eptifibatide
(GPI)
Double bolus of 180 µg/kg
(given at a 10-min interval)
Maintenance infusion of
2.0 µg/kg/min for up to 18 hours
Tirofiban
(GPI)
Bolus of 25 µg/kg over 3 min Maintenance infusion of
0.15 µg/kg/min for up to 18
hours
Cangrelor Bolus of 30 µg/kg Maintenance infusion
4 µg/kg/min for at least 2 hours
or duration of the procedure,
whichever is longer
* Abciximab may not be readily available to clinicians in the U.S.
