Other Conditions
20
Table 6. Safety of Medications for Weight Reduction in
Obesity
Medication Contraindications
Orlistat Chronic malabsorption, cholestasis,
pregnancy
Phentermine/topiramate Use with MAO inhibitors,
hyperthyroidism, glaucoma, pregnancy
Naltrexone/bupropion Uncontrolled hypertension, seizure
disorders, anorexia, bulimia,
abrupt discontinuation of alcohol,
benzodiazepines, or barbiturates, pregnancy
Liraglutide 3 mg Personal or family history of medullary
thyroid carcinoma or multiple endocrine
neoplasia type 2, pregnancy
From prescribing information Roche Laboratories Inc. Prescribing Information for Xenical
(orlistat) 1999; VIVUS Inc. Prescribing Information for Qsymia (phentermine/topiramate) 2012;
Nalpropion Pharmaceuticals Inc. Prescribing Information for Contrave (naltrexone hydrochloride
and bupropion hydrochloride) 2020; Novo Nordisk. Prescribing Information for Victoza
(liraglutide) 2020.
