19
LDL-C reduction Major drug interactions
15–20 % Cyclosporine, fenofibrate, fibrates,
cholestyramine
56–61% on background of statin None known
63–71% on a background of a statin;
41–45% on background of statin +
ezetimibe
None known
12%–25% When given concomitantly with warfarin,
thiazide diuretics, thyroxine, estrogens and
progestins, tetracycline, phenobarbital,
penicillin G, acetaminophen, phosphate
supplements
15–18% When given concomitantly with oral
contraceptives, levothyroxine, warfarin,
glimepiride, glipizide, phenytoin
–18% on a background of a statin Limit simvastatin to 20 mg, limit
pravastatin to 40 mg, cyclosporine
From prescribing information for Daiichi Sankyo Inc. 2020, Ohm Laboratories Inc. 2020, Amgen
Inc. 2017, Sanofi-Aventis U.S. LLC 2018, Eon Labs 2020, Esperion erapeautics 2020. All
medications are to be used as adjunct to diet and exercise.
