7
Pancreas
Increased circulating f ree fatty acid
delivery and increased glucose exposure
to pancreatic beta cells may reduce
insulin secretion due to gluco-lipotoxicity
• Increased sphingolipid (e.g., ceramide)
formation promotes pancreatic beta
cell apoptosis
• Reduction in liver and pancreas fat
content with weight loss in patients
with overweight/obesity may allow
recovery of beta cell function, especially
among patients with shorter duration
of type 2 diabetes mellitus
Increased Circulating
Free Fatty Acids
