OMA Guidelines Bundle

Obesity-Related Diseases - Obesity Algorithm 2024

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6 Disease Categories How Does Obesity (Adiposopathy) Cause Diabetes? Adiposopathic Lipotoxicity and Diabetes Liver and Muscle Increased tissue FFA lead to an increase in intracellular binding of FFA to sphingolipids forming "toxic" ceramides and its metabolites: • Mitochondrial dysfunction • Endoplasmic reticulum "stress" • Impaired insulin receptor function • Impaired glucose transporter expression (glucose transporter 2 [GLUT2] for liver, GLUT4 for muscle and adipose tissue) Adipose Tissue During positive caloric balance, impaired uptake of energy in "sick" adipose tissue leads to increased circulating free fatty acids and "ectopic" and pathogenic deposition of fatty acids and fats: • Visceral, pericardial, and perivascular fat • Fatty liver • Fatty muscle • Fatty heart • Pancreas fat infiltration Treatment of Adult Patients With Overweight or Obesity Immunopathies Endocrinopathies Insulin resistance and beta-cell dysfunction Adiposopathic ("Sick Fat Disease")

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