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8. The relative adiposopathic lack of uptake of FFA in peripheral
subcutaneous AT results in energy overflow with FFA deposition
in abdominal subcutaneous tissue, visceral AT, and pericardial AT,
as well as FFA deposition in organs such as muscle and liver.
9. Increased FFA delivery to the liver from adiposopathy and/
or triglyceride-rich lipoproteins may lead to fatty liver and
fatty muscle, possible "lipotoxicity" to these organs, increased
circulating VLDL (with increased triglyceride levels), increased
lipoprotein remnants, reduced HDL-C, and increased proportion
of smaller, more dense low density lipoprotein (LDL) particles
— all representing an adiposopathic dyslipidemia which is
atherogenic.
10. Weight loss decreases atherogenic apolipoprotein B-containing
lipoproteins and increases high density lipoprotein cholesterol.
