7
Concomitant Pharmacotherapy
Variable effects on body weight:
• Some tricyclic antidepressants (secondary amines)
▶ Desipramine
▶ Nortriptyline
▶ Protriptyline
• Some selective serotonin reuptake inhibitors
▶ Escitalopram ▶ Sertraline
• Some serotonin and norepinephrine re-uptake inhibitors
▶ Desvenlafaxine ▶ Duloxetine
• Some irreversible MAOIs (i.e., tranylcypromine)
• Some other serotonergic agents
▶ Vortioxetine
Mood Stabilizers
May increase body weight:
• Gabapentin
• Divalproex
• Lithium
• Valproate
• Vigabatrin
• Cariprazine
• Carbamazepine
Variable/neutral effects on body weight:
• Lamotrigine (sometimes reported to decrease body weight)
• Oxcarbazepine
Migraine Medications
May increase body weight:
• Amitriptyline
• Gabapentin
• Paroxetine
• Valproic acid
• Some beta-blockers
May decrease body weight:
• Topiramate • Zonisamide
Neutral effects on body weight:
• Non-steroidal anti-
inflammatory drugs (NSAIDs)
• Triptans (e.g., sumatriptan,
rizatriptan, zolmitriptan)
• 5-HT 1F receptor agonist
(i.e., lasmiditan)
• Dihydroergotamine
• Calcitonin gene-related peptide
receptor (CGRP) receptor
antagonists (e.g., ubrogepant,
rimegepant, galcanezumab,
atogepant)
(cont'd)
