6
Effects of Concomitant Medications on Weight
(cont'd)
Concomitant Pharmacotherapy
Hormones (cont'd)
Variable effects on body weight:
• Progestin contraceptives
▶ Injectable or implantable progestins may have greatest risk for
weight gain
• Testosterone
▶ May reduce percent body fat and increase lean body mass,
especially if used to replace testosterone def iciency in men
Anti-seizure Medications
May increase body weight:
• Carbamazepine
• Gabapentin
• Valproate
• Pregabalin
May decrease body weight:
• Topiramate • Zonisamide
Antidepressants
May increase body weight (reports on body weight not always
consistent):
• Some tricyclic antidepressants (tertiary amines)
▶ Amitriptyline
▶ Doxepin
▶ Imipramine
▶ Dosulepin
• Some selective serotonin reuptake inhibitors (e.g., paroxetine,
citalopram)
• Some selective serotonin and norepinephrine re-uptake inhibitors
(e.g., venlafaxine)
• Some irreversible monoamine oxidase inhibitors (MAOI) (e.g.,
isocarboxazid, phenelzine)
• Trazodone
• Mirtazapine
• Brexpiprazole
May decrease body weight:
• Bupropion • Fluoxetine (variable)
(cont'd)
