5
Effect of
Eating on
Hormone
Secretion Notes
Effect of Gastric
By-pass and Sleeve
Gastrectomy
With fasting
Gastric emptying/
growth hormone (GH)
Ghrelin likely to
decrease with sleeve
gastrectomy (not so
with gastric bypass)
Hydrochloride (HCI) acid and
pepsinogen
Gastric bypass
−/ Sleeve
Hunger with hypoglycemia
Glucose transporter 4 in adipose
tissue/muscle, glycogenesis,
lipoprotein lipase activity,
lipogenesis
Insulin resistance/
fasting insulin
Insulin sensitivity/
insulin
responsiveness
Glycogen to glucose
Postprandial glucagon in patients
with type 2 diabetes mellitus
(glucagon not suppressed)
Variable
Pancreatic exocrine secretion
Variable
Gastric emptying, glucagon −/
Growth hormone, gastrin, HCI,
secretin, CCK, insulin, glucagon
−/
Gall bladder contractility and bile,
pancreatic enzymes
Gastric emptying
Postprandial
Pancreatic bicarbonate and bile
Intestinal motility and gastric acid
Variable
Insulin
Glucagon postprandial
Variable
( with
fasting)
Gastric motility, interdigestive
migratory contractions
(borborygmi)
?
