APA Guidelines Bundle

Treatment of Patients with Schizophrenia

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20 Treatment Long-acting injectable antipsychotic medications: dosing* Generic name Trade name Dose conversions Initial dose (mg) First-generation antipsychotics Fluphenazine Prolixin Decanoate For each 10 mg/day oral, give 12.5 mg decanoate every 3 weeks 6.25–25 every 2 weeks Haloperidol Haldol decanoate For each 5 mg/day oral, give 50–75 mg decanoate every 4 weeks Determined by oral dose and/or risk of relapse up to a maximum of 100 mg Second-generation antipsychotics Aripiprazole monohydrate Abilify Maintena Not applicable 400 Aripiprazole lauroxil Aristada Initio Not applicable 675 Aripiprazole lauroxil Aristada 10 mg/day orally, give 441 mg IM/month 15 mg/day orally, give 662 mg/month IM, 882 mg IM every 6 weeks, or 1,064 mg IM every 2 months 20 mg/day or greater orally, give 882 mg/ month IM Monthly: 441, 662, 882 Every 6 weeks: 882 Every 2 months: 1,064

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