15
Table 4. Key Differential Diagnoses for Sarcoidosis within
Individual Organ Systems
Parotid/
salivary/lacrimal
glands
Granulomatosis polyangiitis
Ductal obstruction (calculus, tumor)
Crohn's disease
Bacteria
• Tuberculosis
• Atypical mycobacteria
Heart Giant cell myocarditis
Acute rheumatic heart disease
Granulomatosis with polyangiitis
Erdheim-Chester
Arrhythmogenic right ventricular
dysplasia
Foreign body
Drugs/toxins
Granulomatous lesions of unknown
significance
Bacteria
• Tuberculosis
• Syphilis
• Tropheryma whippelii
Fungi
• Aspergillus
Spleen Chronic variable immunodeficiency
Sarcoid-like reaction to tumor
Bacteria
• Tuberculosis
Fungi
• Histoplasmosis
Parasites
• Leishmaniasis
Kidney Granulomatosis polyangiitis
Chronic lymphocytic leukemia
Drugs
• Allopurinol
• Antivirals
• Anticonvulsants
• β-Lactams
• Diuretics
• Erythromycin
• Fluoroquinolones
• NSAIDs
• Proton pump inhibitors
• Rifampin
• Sulfonamides
• Vancomycin
Bacteria
• Tuberculosis
Fungi
• Histoplasmosis
• Coccidioidomycosis
Viral
• Adenovirus
Muscle Non-Hodgkin lymphoma
Crohn's disease
ymoma-myasthenia gravis
Foreign body
Primary biliary cirrhosis (primary
biliary cholangitis)
Cryofibrinogenemia
Bacteria
• Tuberculosis
• Syphilis
• Brucella
Fungi
• Pneumocystis jirovecii
• Cryptococcosis
Virus
• Human
T-lymphotrophic virus 1
