13
Organic exposure, small poorly formed interstitial granulomas in interstitium,
prominent lymphocytic infiltrates, chronic inflammatory infiltrates accentuated around
bronchioles
Aerosolized water exposure, MAC cultured from sputum, lung or hot tub, large well-
formed granulomas in bronchiole lumens
Inorganic exposure history
Usually nonnecrotizing granulomas. Drug exposure history essential.
See www.pneumotox.com for full list
Serum ACE elevated in many patients; particles found on biopsy; perivascular
granulomas
Central lipid vacuole; ingestion of mineral oil or hepatic steatosis
Multisystemic; well formed, usually nonnecrotic granulomas
Granulomatous pneumonitis with necrosis and vasculitis; multiple necrotic lung
nodules
Cervical lymphadenopathy and low-grade fever. Granulomas are not found, although
necrotic areas with histiocytes are present
Lacks progressive lung parenchymal disease, elevated serum calcium,
1,25-dihydroxyvitamin D, and ACE
Associated with asthma and Aspergillus infection in 50%. Necrotizing granulomas
exclusively in bronchi and bronchioles
