15
Common Dosing Advantages Disadvantages
Range: 60mg–120mg
(daily)
Strongest retention in
treatment; improved
social functioning
associated with reductions
in criminal activity,
recidivism, and infectious
disease acquisition and
transmission
More frequent clinic visits;
only SAMHSA-certified
OTPs may provide
methadone for addiction
treatment; higher risk for
respiratory depression
due to long half-life and
stacking effect (requires
more monitoring )
Range: 4mg–24mg (daily) Ceiling effects on
respiratory depression;
more rapid induction
to steady state dose; less
potential for euphoria
(compared to methadone);
considered safe for office-
based treatment; improved
social functioning ;
associated with reductions
in criminal activity,
recidivism, and infectious
disease acquisition and
transmission
Requires X-Waiver to
prescribe; risk for overdose
when combined with
alcohol, benzodiazepines,
or other sedatives
Range: 4mg/1mg to
24mg/6mg (daily)
Range: 2.9mg/0.71mg to
17.2mg/4.2mg (daily)
Range: 2.1mg/0.3mg to
12.6mg/2.1mg (daily)
Range: 4mg/1mg to
24mg/6mg (daily)
(daily)
