17
Common Dosing Advantages Disadvantages
Range: 100mg to 300mg
(monthly)
Ceiling effects on
respiratory depression;
more rapid induction
to steady state dose; less
potential for euphoria
(compared to methadone);
considered safe for office-
based treatment; improved
social functioning ;
associated with reductions
in criminal activity,
recidivism, and infectious
disease acquisition and
transmission
Requires X-Waiver to
prescribe; risk for overdose
when combined with
alcohol, benzodiazepines,
or other sedatives
Range: 8mg–32mg
(weekly) or Range
64–128mg (monthly)
4 implants for 6 months of
treatment
Range: 25mg–50mg
(daily)
No risk for misuse or
physiological dependence;
no special regulatory
requirements; improved
social functioning ;
associated with reductions
in criminal activity and
recidivism; and infectious
disease acquisition and
transmission
Patients must be fully
withdrawn from opioids
before beginning
treatment, lower retention
in treatment, high rates of
medication non-adherence,
has not been demonstrated
to reduce mortality (and
may increase mortality
risk aer medication
discontinuation)
Range: 380mg (monthly)
