Comments
Administer with or without food.
Causes or exacerbates
CHF in some patients.
If signs and symptoms
of CHF develop,
treat accordingly and
discontinue TZD.
Contraindicated in
NYHA Class III or IV
CHF. Administration
in patients receiving
insulin or nitrates is not
recommended.
Replacing rosiglitazone and metformin taken separately as
combination therapy, or if uncontrolled on rosiglitazone or
metformin alone.
Administer in divided doses with meals to reduce GI side effects
associated with metformin.
Replacing rosiglitazone and SU taken separately as combination
therapy, or if uncontrolled on rosiglitazone or SU alone.
Administer with first meal of the day.
Table 13. Summary of Insulin Regimens
Insulin
Regimen
Components and Frequency of Administration
Injections
per Day
Basal
Levemir® (daily or twice a day)
Lantus® (once daily)
Premixed
NovoLog® Mix 70/30 or Humalog® Mix 75/25™
(usually twice a day; occasionally used daily or 3 times a day)
2
Prandial/
mealtime
Apidra®, NovoLog®, or Humalog® (with meals)
3
Basal-bolus
(multiple daily
injections)
Apidra®, NovoLog®, or Humalog® (with meals) in
combination with detemir or glargine (daily)
4
Continuous
subcutaneous
insulin infusion
Apidra®, NovoLog®, or Humalog®
1 or 2
1
Continuous
Insulin Time-action Profiles
Relative Insulin Effect
Rapid (aspart, glulisine, lispro)
Short (Regular)
Intermediate [NPH]
Basal (detemir or glargine)
0
2
4
6
8
10
12
14
16
18
20
Time (hours)
25
