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Abbreviations 5HT2c, 5-hydroxytryptamine receptor-2C; ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blockers; BMI, body mass index; BP, blood pressure; CVD, cardiovascular disease; DMARD, disease-modifying antirheumatic drugs; EMA, European Medicines Agency; ER, extended release; ES, Endocrine Society; GABA, gamma-amino-butyric acid; GLP-1, glucagon-like peptide-1; HR, heart rate; HTN, hypertension; IUD, intrauterine device; MAO, monoamine oxidase; NAFLD, nonalcoholic fatty liver disease; SGLT, sodium-glucose linked transporter; SNRI, serotonin-norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; T2DM, type 2 diabetes mellitus Source Apovian CM, Aronne LJ, Bessesen DH, et al. Pharmacological Management of Obesity: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(2):342–62. Grading System Strength of Recommendation 1 = strong 2 = less strong U = ungraded Quality of Evidence ⊕⊕⊕⊕ = high ⊕⊕⊕ = moderate ⊕⊕ = low ⊕ = very low 106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies, GuidelineCentral.com Copyright © 2015 All rights reserved ESOBE15093 Disclaimer is Guideline attempts to define principles of practice that should produce high-quality patient care. It focuses on the needs of primary care practice, but also is applicable to providers at all levels. is Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. e ultimate judgment concerning the propriety of any course of conduct must be made by the clinician aer consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool.

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