Warnings and Precautions Contraindications
• Should not be used with other drugs for
weight loss
• Pulmonary hypertension (use >3 months
associated with a 23-fold increase)
• Valvular heart disease
• Treatment should be continued only if the
patient has lost at least 4 pounds in first 4 weeks
• Tolerance to anorectic effect
• May impair the ability to engage in potentially
hazardous activities
• Dependence with withdrawal syndrome on
cessation
• Hallucinations
• Toxic psychosis
• Possibility of adverse interactions with alcohol
• Pulmonary hypertension
• Advanced arteriosclerosis
• Hyperthyroidism
• Known hypersensitivity or idiosyncrasy
• Glaucoma
• Severe hypertension
• Agitated states
• History of drug abuse
• Use in combination with other anorectic
agents
• During or within 14 days of taking
MAOIs
• Can decrease cyclosporine exposure
• Take a multivitamin supplement
• Rare cases of severe liver injury
• Monitor renal function in patients at risk for
renal insufficiency
• Weight loss can increase the risk of
cholelithiasis
• GI events with a diet high in fat
• Cyclosporine (taken 2 hours before or
after orlistat dose)
• Chronic malabsorption syndrome
• Pregnancy and breastfeeding
• Cholestasis
• Levothyroxine
• Warfarin
• Antiepileptic drugs
• Known hypersensitivity
• See Orlistat prescription • See Orlistat prescription
• Boxed Warning :
▶ Suicidal behavior and ideation
• Warnings:
▶ Risk of seizure (adhere to dosing schedule
and avoid coadministration with high-fat
meal)
▶ Increase in blood pressure and heart rate
▶ Hepatotoxicity
▶ Angle-closure glaucoma
▶ Weight loss may cause hypoglycemia
• Uncontrolled hypertension
• Seizure disorders
• Anorexia nervosa or bulimia
• Drug or alcohol withdrawal
• MAO inhibitors
• Chronic opioid use
• Known allerg y
• Pregnancy
Over-the-counter (Alli), Orlistat prescription (Xenical), Phentermine/topiramate (P/T) (Qsymia)
