➤ In patients presenting with a strong clinical phenotype for PCD, the ATS
suggests using an extended genetic panel (>12 genes) as a diagnostic test
over TEM ciliary testing and/or standard (≤12 genes) genetic panel testing
(conditional recommendation, moderate certainty of evidence in test
accuracy but very low certainty in the overall evidence).
➤ In cooperative patients 5 years of age or older with a clinical phenotype
consistent with PCD and with CF excluded, the ATS suggests using nNO
testing with chemiluminescense technology and standardized protocol
for the diagnosis of PCD over TEM and/or genetic testing (conditional
recommendation, moderate certainty in test accuracy but very low
certainty in the overall evidence).
➤ The ATS suggests NOT using ciliary beat pattern analysis by high-speed
video microscopy (HSVM) as a replacement diagnostic test in patients
with a high probability of having PCD (conditional recommendation, low
certainty in the diagnostic accuracy of the test but very low certainty in
the overall evidence).
➤ The ATS suggests NOT using ciliary beat frequency (CBF) measurement
as a diagnostic test in patients with a high probability of having PCD
(conditional/weak recommendation, low certainty in the diagnostic
accuracy of the test but very low certainty in the overall evidence).
Diagnosis
