AASLD Hemochromatosis

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Diagnosis Key Points Table 1. Classification of Iron Overload Syndromes Hereditary Hemochromatosis HFE-related C282Y/C282Y C282Y/H63D Other HFE mutations Non–HFE-related Hemojuvelin (HJV) Transferrin receptor-2 (TfR2) Ferroportin (SLC40A1) Hepcidin (HAMP) African iron overload Secondary Iron Overload Iron-loading anemias Thalassemia major Sideroblastic Chronic hemolytic anemia Aplastic anemia Pyruvate kinase deficiency Pyridoxine-responsive anemia Parenteral iron overload Red blood cell transfusions Iron–dextran injections Long-term hemodialysis Chronic liver disease Porphyria cutanea tarda Hepatitis C Hepatitis B Alcoholic liver disease Nonalcoholic fatty liver disease Following portocaval shunt Dysmetabolic iron overload syndrome Miscellaneous Neonatal iron overload Aceruloplasminemia Congenital atransferrinemia

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