Grading of Recommendations, Assessment, Development,
and Evaluation (GRADE)
Strength of
Recommendation
Criteria
Strong (1)
Factors influencing the strength of the recommendation included the
quality of the evidence, presumed patient-important outcomes, and cost
Weak (2)
Variability in preferences and values, or more uncertainty.
Recommendation is made with less certainty, or higher cost or resource
consumption
Quality of Evidence
Criteria
High (A)
Further research is unlikely to change confidence in the estimate of the
clinical effect
Moderate (B)
Further research may change confidence in the estimate of the clinical
effect
Low (C)
Further research is very likely to impact confidence on the estimate of
clinical effect
Abbreviations
AASLD, American Association for the Study of Liver Diseases; ALT, alanine aminotransferase;
AST, aspartate aminotransferase; C282Y, Cys282Tyr mutation; H63D, His63Asp mutation;
HAMP, hepcidin; HCC, hepatocellular carcinoma; HH, hereditary hemochromatosis; HIC,
hepatic iron concentration; HJV, hemojuvelin; Tf R2, transferrin receptor-2; TS, transferrin
saturation
Source
Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS; American Association for the Study
of Liver Diseases. Diagnosis and management of hemochromatosis: 2011 practice guideline by
the American Association for the Study of Liver Diseases. Hepatology. 2011 Jul;54(1):328-43.
PMID: 21452290
Disclaimer
This Guideline attempts to define principles of practice that should produce high-quality patient care.
It focuses on the needs of primary care practice, but also is applicable to providers at all levels. This
Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining
the same results. The ultimate judgment concerning the propriety of any course of conduct must be
made by the clinician after consideration of each individual patient situation.
Neither IGC, the medical associations, nor the authors endorse any product or service associated with
the distributor of this clinical reference tool.
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