Treatment
Table 5. Influenza Antiviral Therapy Please check the CDC website (http://www.flu.gov/) for current susceptibility data.
Drug (Brand)
Oseltamivir (Tamiflu®
)
Dosing Recommendations Treatment
Formulations
75-mg capsule; 60 mg/5 mL suspension
Children
For treatment, children ≥ 24 mo should receive approximately 4 mg/kg/day div bid for a 5-day treatment course
60 mg/day div bid 90 mg/day
≤ 15 kg > 15-23 kg > 23-40 kg > 40 kg div bid 120 mg/day
div bid
For treatment of infants < 24 mo of age: 9-23 mo: 7 mg/kg/day div bid 0-8 mo: 6 mg/kg/day div bid Premature infants: 2 mg/kg/day div bid
Zanamivir (Relenza®
) 5 mg per
Amantadine (Symmetrel®
inhalation, using a Diskhaler®
)a
100-mg tablet; 50 mg/5 mL suspension
Children ≥ 7 y and Adults
2 inhalations (10 mg total per dose) bid for 5 days
Adamantane-Based Drugs (not currently used due to resistance) 1-9 y
5-8 mg/kg/day as a single daily dose or div bid, but not to exceed 150 mg/day.
Rimantadine (Flumadine®
)a
100-mg tablet; 50 mg/5 mL suspension
1-9 y
6.6 mg/kg/day div bid (max 150 mg/kg/day)
9-12 y
200 mg/day div bid (not studied as a single daily dose)
≥ 10 y
Not FDA approved for treatment in children, but published data exist on safety and efficacy
200 mg/day, either as a
single daily dose, or div bid
a Amantadine and rimantadine should only be used for treatment and prophylaxis in winter seasons during which a majority of influenza A virus strains isolated are adamantane-susceptible; the adamantanes should NOT be used for primary therapy because of the rapid emergence of resistance. However, for those requiring adamantane therapy, a treatment course of approximately 7 days is suggested, or 24-48 hours aſter the disappearance of signs and symptoms.
16
200 mg/day, either as a single daily dose, or div bid
200 mg/day, either as a single daily dose, or div bid
div bid 150 mg/day Adults
150 mg/day div bid for 5 days
